If the fuse is OK, then it's either a poor engine earth - but I'd expect a lot of other DTC's or odd behaviour, or a wiring fault.
If the fuse is intact and you press the start button, with a faulty starter motor, you'd see some dimming of the interior lights and flickering of the dash lights etc. Besides, the starter motor is electrically isolated when not cranking so that wouldn't cause the fuse to rupture during driving. The alternator is of course, connected to the battery whilst driving, assuming an internal defect in the rectifier pack or windings caused a short to ground, that would initially draw lots of current from the battery in a short time until the fuse ruptures (the fuse may well have ruptured after the vehicle came to a halt).
All of the above assumes that the mega-fuse has blown due to an alternator fault and not due to previous attempts to start the engine after it stopped (which you didn't mention so I'm assuming there were none) and the fuse has blown due to a seized engine causing excessive current to be drawn by the starter motor - which would give the same DTC's once communication with the alternator was lost. The basic check for this is to rotate the crank pulley in a clockwise direction only, if you get 'soft' resistance, rest for a few seconds and go again, aiming for two complete revolutions (put a Tippex or crayon mark on the pulley first). If you get 'hard' resistance (sudden stop, not gradually increasing), then it's likely to have suffered a catastrophic failure internally.