As commented, my 101 ambi is LHD. In the uk, theres times when you come up to an angled T junction, indicating left, but fools still come up the left hand side, as your road position makes it look as if youre turning right.
Really, what ive done is position the vehicle such as i an actually see down the road to my right. The little window behind the (in my case, passenger) seat helps a little,but not by much.
I think, with a PAS conversion (which mine does not have) and decent tyres (which mine does have) theyre would be no more bothersome to drive than any other large vehicle. Sure theyre heavy, and have drum brakes, and leaf springs, but you just compensate a bit. Its not like, in a motor home, theres ever much point in pusing the edge, with regard to speed.
My (diesel converted) will do 60 all day long without stress - probably 65. Its possible to exceed the speed limit with it, but, at that sort of speed, youre eyes want to be on the road, and not on the dashboard... (i have altered the transfer gears, but dont have an overdrive)
Big truck mirrors will, im sure, make things better. They look a bit silly on a GS, but ive seen them on ambis before, they look the part. I have a set, but not fitted yet.
The bonus of being able to adjust the mirror from the driving position (theyre motorised) will be huge.
Reversing cameras are another cheap mod, that, i think, will make things easier.
If i get an MOT on mine at any time soon, ill happily take you out for a drive. If you can prove to me 100%, beyond any doubt at all, that your insurance would compensate me to 100% of its insured value, then id be happy for you to drive it also.