It wouldn't run at all if it was 180 degrees out...you'd be firing at the bottom of the stroke, when the mixture isn't compressed, so won't really do anything. You might get a backfire if the mixture ignites as the exhaust valve starts to open.
You could check the accuracy of the pulley notch by using a very clean, think stick in the plug hole and rocking the engine back and forwards to get it spot on TDC, but I think the fact that it's mostly OK and you're detecting the loss in power at 6 degrees ATDC, you're probably about right and you've not got a pulley with it's notch way out like mine was, so I would guess you are about right with how you've set it.