The first thing to say is that I haven't got the replacement yet so not had a proper go but...
If I don't remove the spare, can I get the wiper arm far enough from the window to replace the blade?
Numpty-proof instructions appreciated.
If you're just replacing the wiper blade, no it's not necessary but you might have to stop the wiper at a point which allows the best access.
If you're replacing the complete wiper arm and blade, yes you will have to.