If they are really rusted in, even getting the flange red hot won't always budge them, so you may end up having to drill them out and re-tap the holes.
They are steel studs into cast iron, so normally they are not too bad a job to do, but you need the manifolds off the engine and the tools to do the job.
We had all of ours out originally when we did the engine, and fitted another set a week of so back when we had the clutch changed, Use Copaslip on all the threads, new studs and nuts aren't too expensive.
Peter